Neurobiology of Disease L-DOPA Impairs Proteasome Activity in Parkinsonism through D1 Dopamine Receptor
نویسندگان
چکیده
Amandine Berthet,1 Erwan Bezard,1,2 Gregory Porras,1 Stefania Fasano,3 Pedro Barroso-Chinea,1 Benjamin Dehay,1 Audrey Martinez,1 Marie-Laure Thiolat,1 Marika Nosten-Bertrand,4 Bruno Giros,4 Jérôme Baufreton,1 Qin Li,2 Bertrand Bloch,1 and Marie-Laure Martin-Negrier1 1Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, 33076 Bordeaux, France, 2Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, 100050 Beijing, China, 3Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Foundation and University, 20132 Milano, Italy, 4INSERM UMRS-952/CNRS UMR 7224, Université Pierre et Marie Curie, 75252 Paris, France
منابع مشابه
L-dopa impairs proteasome activity in Parkinsonism through D1 dopamine receptor.
Aberrant membrane localization of dopamine D(1) receptor (D1R) is associated with L-DOPA-induced dyskinesia (LID), a major complication of L-DOPA treatment in Parkinson's disease (PD). Since the proteasome plays a central role in modulating neuronal response through regulation of neurotransmitter receptor intraneuronal fate, we hypothesized that the ubiquitine-proteasome proteolytic pathway cou...
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